Schizophrenia (SZ) is one of the most common and severe psychiatric disorders with a heritability estimated to be about 80%. In recent years, significant progress has been made to elucidate the genetic and molecular mechanisms underlying schizophrenia. However, the causal genes and pathways remain largely unclear. Here we developed the schizophrenia database (SZDB), a comprehensive resource for schizophrenia research. Currently, SZDB collected and integrated schizophrenia related data from the following source: genetic data (SNP associations from the PGC2, genome-wide significant SNPs and genes, genes affected by CNVs, genes from convergent functional genomics (CFG), genes from Sherlock integrative analysis, and genes identified by association and linkage studies), gene expression data (spatio-temporal expression pattern and differentially expressed genes), network-based data (PPI and co-expression), brain eQTL data, ENCODE data, as well as SNP function annotation information. In-depth analyses and systematic integration are performed, including SNP and gene annotation, spatio-temporal expression pattern analysis, network (PPI and co-expression) and pathway analysis, brain eQTL analysis and gene prioritization. SZDB also provides an online analysis toolkit for conducting customized analysis.

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snp expression ppi
Search SNP Expression pattern Protein-Protein interaction Differential expression Regional association

Cited us: Yong Wu, Yong-Gang Yao and Xiong-Jian Luo. SZDB: A Database for Schizophrenia Genetic Research. Schizophrenia Bulletin (2017) 43 (2): 459-471.